Roles of Quercetin and Omeprazole in Ovotoxicity Induced by Indomethacin in Wistar Rats
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Abstract
Background
Quercetin, a flavonoid in fruits and vegetables, offers health benefits like anti-carcinogenic, anti-inflammatory, and antioxidant effects. This work investigated role of quercetin against indomethacin-induced histological and functional changes in the ovaries of female Wistar rats.
Methods
25 adult female Wistar rats with an average weight of 150 g (± 10 g) were used in the experiment, they were randomly assigned into 5 groups. All animals except those in control group (group A) were given a single oral dose of 30 mg/kg of indomethacin. Group B - induced with (30mg/kg) indomethacin only, in addition group C, D, E received, omeprazole, quercetin (50mg/kg), omeprazole (20mg/kg) and quercetin (50mg/kg) respectively. All administration were done orally for 30days.
Results
Reduced FSH serum levels were observed in the indomethacin and omeprazole treated group compared to other groups. There was a reduction of LH serum in the indomethacin and omeprazole treated group compared to the control group. Serum lipid peroxidase level concentration was significantly elevated in the indomethacin only treated group compared to the control and all other treated groups. Histological evaluation revealed pathological changes in the indomethacin only treated group.
Conclusions
Indomethacin negatively impacts ovarian function while quercetin confers a protective role. The triple combination of indomethacin, omeprazole, and quercetin shows observable positive effect of quercetin against indomethacin-induced ovotoxicity
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